The cause of clubfoot is not known. There are studies, however, that have linked the congenital deformity with the use of Selective Serotonin Reuptake Inhibitors (SSRIs) while pregnant. Some studies suggest that babies are more likely to be born with clubfoot if their mothers took antidepressants while pregnant. Some mothers who took certain antidepressants like Effexor, Pristiq, Celexa, Lexapro, and Zoloft, have reported that they have had babies born with clubfoot.
The authors of a July 2007 article in the New England Journal of Medicine showed concern over the higher occurrence of clubfoot in infants whose mothers took SSRIs while pregnant. Researchers stated that the association between certain antidepressants and higher incidence of congenital clubfoot “warrants further exploration.”
A study conducted by the Institute of Reproductive Toxicology at the University of Ulm, Germany, also found a connection between the ingestion of SSRIs during pregnancy and a higher rate of congenital clubfoot birth defect.