Leading Zantac Lawyers in the Country Over $4 Billion in Verdicts & Settlements

Reasons to Choose Us:

  • Our Attorneys Are Recognized as Some of the Top Plaintiff Lawyers
  • Strong Reputation for Successfully Litigating Against Big Pharma
  • Advocating Tirelessly to Protect Consumers Against Dangerous Drugs
  • $2.055 Billion Verdict, the Second-Largest Personal Injury Verdict in the Nation in 2019, and the Ninth-Largest Personal Injury Verdict in American History

Zantac Cancer Lawsuits

FDA Links Ranitidine to NDMA and Cancer

You may have already heard in the news that Zantac (ranitidine) has been linked to cancer, and that recent lawsuits against Zantac manufacturers allege the drug contains a cancer-causing chemical called N-Nitrosodimethylamine (NDMA). At Baum Hedlund Aristei & Goldman, our award-winning attorneys are representing people from across the country in personal injury and wrongful death Zantac lawsuits. We intend to hold the drug makers accountable for allegedly concealing the Zantac cancer link and putting profit before people.

IMPORTANT ZANTAC UPDATE: The U.S. Food and Drug Administration announced on April 1, 2020 that it is requesting manufacturers to withdraw all Zantac and generic Zantac OTC ranitidine drugs from the market effective immediately. The FDA determined that N-Nitrosodimethylamine (NDMA) in some ranitidine medications “increases over time and when stored at higher than room temperatures and may result in consumer exposure to unacceptable levels…” The FDA, the Environmental Protection Agency (EPA), and the World Health Organization (WHO) all classify NDMA as a cancer-causing substance.

Contact Baum Hedlund at (855) 948-5098 or contact us online to see if you may be eligible to seek compensation for Zantac cancer losses.

What Is Zantac?

Chemically known as ranitidine hydrochloride, Zantac belongs to a class of drugs called histamine H2-receptor antagonists (or H2 blockers), which decrease the amount of acid produced by the stomach. Zantac is a very popular antacid medication that has been on the market since the early 1980s, available both over the counter and by prescription. People commonly use Zantac for acid reflux, heartburn, and a host of other stomach, throat, and gastrointestinal issues. Others use Zantac for allergies to supplement their treatment regimen.

Zantac dosage varies between 75 and 150 mg tablets, though some patients take a once daily Zantac 300 mg dosage.

Since the 1980s, numerous studies have demonstrated a link between the NDMA in Zantac and cancer. Mounting evidence also allegedly shows that Sanofi and Boehringer Ingelheim, the big pharma companies that make Zantac (ranitidine hydrochloride), concealed the Zantac cancer link from millions of people who took the drug for heartburn, gastric and duodenal ulcers, gastroesophageal reflux disease (GERD), sour stomach, Barrett’s esophagus, acid reflux, and other issues. This deception came as the companies made unprecedented profits from Zantac, the first drug to generate $1 billion in sales.

Baum Hedlund continues to operate amid the Coronavirus outbreak. As the health and safety of our clients and staff remain our greatest concern, under the governmental guidelines, we are working remotely for the foreseeable future. We are fully equipped to continue to diligently represent each of our clients and accept new clients in the pursuit of justice.

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Billions Won for Our Clients

  • Paxil Pediatric Class Action $63 Million
  • Third-Party Payer Class Action $40 Million
  • Defective Drug Class Action $28 Million
  • Celexa-Lexapro Pediatric Class Action $10 Million
  • Drug Injury $9 Million
  • Pharmaceutical Settlement $105 Million
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Zantac Side Effects

The link between Zantac and cancer goes back decades. Our firm represents people from across the country with the following Zantac side effects:

  • Bladder cancer
  • Brain cancer
  • Breast cancer
  • Esophageal/nasal/throat cancer
  • Intestinal cancer
  • Kidney cancer
  • Liver cancer
  • Lung cancer (for non-smokers)
  • Ovarian cancer
  • Pancreatic cancer
  • Prostate cancer
  • Stomach cancer
  • Testicular cancer
  • Thyroid cancer
  • Uterine cancer

“We have an epidemic of cancer in our society. For years we have been trying to figure out what’s behind it. Our firm has done a lot of work exposing the causes of non-Hodgkin lymphoma in our Monsanto Roundup litigation. Now we have another source of cancer – it appears that for decades, Zantac has been causing cancer, and we’re only now just seeing it. People from all across the country have cancer today because they took Zantac. That is a wrong that we will fight to make right.”

R. Brent Wisner

Common Zantac Brands

Below are some of the most common Zantac brands and generic ranitidine brand names:

  • Zantac 150 Tablets
  • Zantac 150 Maximum Strength
  • Zantac 150 Maximum Strength Cool Mint
  • Zantac 75 Tablets
  • Wal-Zan 150
  • Wal-Zan 75
  • Heartburn Relief (ranitidine)
  • Acid Reducer (ranitidine)
  • Acid Control (ranitidine)

Ranitidine and NDMA: What Are the Risks?

The U.S. Food and Drug Administration (FDA) announced on September 13, 2019 that it was investigating Zantac cancer risks, after tests of Zantac 150 tablets found the commonly-used heartburn medication contains NDMA at levels up to 3,000 times greater than the FDA’s daily intake limit. With countless people now stricken with cancer after taking Zantac, many are turning to the courts and filing a Zantac lawsuit to hold Sanofi and Boehringer Ingelheim accountable for their reckless disregard for human health and willingness to put profit over people.

On April 1, 2020, the FDA also issued an immediate market withdrawal request of all Zantac (ranitidine) products after determining that NDMA in “some ranitidine products increases over time and when stored at higher than room temperatures and may result in consumer exposure to unacceptable levels…”

Prior to the FDA market withdrawal of ranitidine, numerous manufacturers issued generic Zantac recalls on their own, including Apotex, Sandoz (Novartis), and GlaxoSmithKline (GSK) after Valisure, an online pharmacy that batch tests the medications it sells, and Emery Pharma, a contract laboratory, found unacceptably high levels of NDMA in ranitidine during testing. Both filed citizen’s petitions with the FDA, urging the agency to suspend sales and issue a Zantac recall. Some versions of Zantac were also recalled in Canada and Europe.

Central to the Zantac cancer risk issue is the known carcinogen NDMA. N-Nitrosodimethylamine (NDMA) is a water-soluble organic (containing the element carbon) chemical and appears as a yellow liquid with little or no obvious taste or odor. It was once used to make rocket fuel but today is made only for research purposes. Nevertheless, it can be produced as a byproduct of manufacturing processes and humans can be exposed to NDMA in relatively small amounts through a variety of products, including tobacco, foods (cured meat, fish, cheese, beer), shampoos, cleansers, and pesticides.

World Health Organization NDMA Investigation

The International Agency for Cancer Research (IARC), a unit of the World Health Organization, is the most recognized cancer research institution in the world. It brings together teams of scientists from multiple countries to investigate the cancer-causing potential of suspect chemicals and substances and publishes papers known as monographs to report the results.

After studying over 200 research papers on NDMA and the NDMA cancer risk, the IARC placed the chemical in the “Group 2A” category, meaning substances that are “probably carcinogenic to humans.” The agency found that NDMA is “carcinogenic in all animal species tested” and noted that the metabolism of NDMA by humans and animals is similar.

NDMA was found to cause malignant tumor growth in multiple organs, in multiple species, by multiple routes of exposure (oral, inhalation, subcutaneous (under the skin), injections), with dose-response relationships appearing in several studies.Scientists are also gaining detailed knowledge of the biochemical mechanisms used by the body to repair NDMA DNA damage and how those mechanisms play a role in the progression towards cancer.

Valisure Study: How Zantac (Ranitidine) Produces NDMA

Recently, multiple generic forms of the blood pressure medication valsartan have been recalled due to contamination by NDMA and another carcinogen, N-Nitrosodiethylamine (NDEA). Investigators discovered that the NDMA in the generics was most likely produced by the actual chemical reactions that take place when valsartan is made. NDMA was introduced during the valsartan manufacturing process itself—not added later as a secondary contamination. This was a consequence of changes in the way valsartan was made.

With Zantac, the source of NDMA appears to be even more dangerous and problematic. In its initial batch testing of Zantac, which was performed according to FDA-recommended protocols, Valisure found levels of NDMA reaching as high as 3,267,968 ng (nanograms) per tablet. The FDA has set the acceptable daily intake of NDMA at 96 ng, or .096 mcg (micrograms). Valisure was looking at NDMA levels that were over 34,000 times higher than the FDA limit.

Wondering if the increased heat of the testing process may have contributed to these results, Valisure decided to test ranitidine in a different way, under conditions that simulated those found in the stomach (simulated gastric fluid with sodium nitrite). NDMA levels, while not as high, were still extraordinary, ranging from 23,600 ng to 304,500 ng, over 3,100 times the FDA’s “safe” limit.

“Valisure’s testing reveals NDMA levels so high that the nitroso for NDMA likely comes from no other source than the ranitidine molecule itself.” [Nitroso refers to an atomic grouping of nitrogen and oxygen, such as found in the nitrite group of NDMA.]

— Valisure Citizen Petition on Ranitidine, September 9, 2019

Valisure also points to a third mechanism that could lead to NDMA production after Zantac is ingested – an enzyme, dimethylarginine dimethylaminohydrolase (DDAH), that can react with ranitidine to “liberate” DMA from ranitidine, making it available to combine with nitrite from the ranitidine molecule, nitrite circulating in the body, or “other potential pathways particularly in weak acidic conditions such as that in the kidney or bladder.” This mechanism, according to Valisure, could generate millions of nanograms of NDMA throughout the body.

Stanford Study Supports Zantac Cancer Link

Additional evidence of a Zantac cancer link comes from research conducted by scientists at Stanford University. Their results were published in 2016 in the journal Carcinogenesis. The researchers tested urine samples from adult volunteers 24 hours before and after ingestion of a standard dose of 150 mg of ranitidine.

They found that levels of NDMA in the urine increased 400-fold, from 110 ng to 47,600 ng. These levels, the authors wrote, severely underestimate the actual NDMA exposure in the body, since only a small fraction of the NDMA is actually excreted in the urine.

Epidemiological Studies of Zantac and Cancer

Very few epidemiological studies of patients taking Zantac have been conducted. In a study conducted by the National Cancer Institute, adult male health professionals with peptic ulcers were followed for 14 years (1986 – 2000). The subjects of the study were asked if they used either Tagamet or Zantac as a treatment. The authors of the study reported that use of either drug was associated with an increased risk of bladder cancer, though the increase fell short of statistical significance.

Other Zantac Studies

A true Zantac cancer study in humans—where humans are deliberately given Zantac to ingest to observe the results—has not been conducted and never will, as it would be unethical. However, a 1983 study of ranitidine in rodents found that it produced several “genotoxic effects,” including DNA fragmentation in the liver and gastric mucosa (the mucous membrane that lines the stomach). Significantly, studies of Tagamet (cimetidine), another antacid in Zantac’s class (H2 blockers), did not show DNA damage.

Genetic damage is known to be at the root of all cancers. A 2013 meta-analysis of studies that examined the relationship between various acid-suppressing drugs and gastric cancer concluded that that “acid suppressive drugs are associated with an increased risk of gastric cancer.”

These studies support three important points underlying the danger posed by Zantac:

  • NDMA is carcinogenic in humans in exceedingly small amounts.
  • Levels of NDMA produced by Zantac are extremely high.
  • The problem with Zantac is not an “impurity” in the drug, but rather the design of the drug itself and how that design makes Zantac itself a carcinogen.

NDMA has not been directly tested in humans. The cancer risk is too high. However, we know from years of research that humans are regularly exposed to NDMA via many foods and beverages. This has provided a means of testing NDMA’s carcinogenic potential—and by extension the carcinogenicity of Zantac—in humans indirectly.

Comparing NDMA in Food and Zantac

We should keep in mind that NDMA is carcinogenic even in very small doses. The U.S. Food and Drug Administration has set the acceptable daily intake of NDMA at 96 nanograms (ng), or 96 billionths of a gram.

Researchers have reported NDMA levels in food ranging from 14 ng per 100 grams (about 3.5 ounces) in whole milk to 10,900 ng per 100 grams of sausage. In the studies covered below you will find elevated cancer risks associated with as little exposure as 179 ng per day. In stark contrast, Valisure, the pharmacy that sounded the alarm on Zantac, reported that one 150 mg tablet of ranitidine produced 304,500 ng of NDMA, 1,700 times the exposure level found to be carcinogenic in some studies.

Which Zantac Brands Have Been Recalled?

To stay as up to date as possible on which Zantac (ranitidine) products have been recalled, we advise you to consult the FDA’s Recalls, Market Withdrawals, & Safety Alerts page.

The following companies issued Zantac voluntary (ranitidine) recalls before the FDA market withdrawal announcement:

  • American Health Packaging
  • Amneal Pharmaceuticals
  • Aurobindo Pharma USA
  • Apotex Corp. (this includes over-the-counter ranitidine tablets 75 mg and 150 mg, labeled by Walgreens, Walmart, and Rite-Aid)
  • Appco Pharma
  • Denton Pharma (dba Northwind Pharmaceuticals)
  • Reddy’s Laboratories (this includes Zantac over-the-counter OTC medicines labeled by retailers such as Walgreens, Walmart, CVS, Target, and Kroger)
  • GlaxoSmithKline (GSK)
  • Glenmark Pharmaceuticals
  • Golden State Medical Supply
  • Lannett Company
  • Novitium Pharma
  • Perrigo Company
  • Precision Dose
  • Sandoz
  • Sanofi

Contact us today at (855) 948-5098 for more information on how we can assist you with filing a Zantac lawsuit.

Zantac Lawsuit FAQs

  • Q:Is My Zantac Lawsuit Part of a Class Action?

    A:It depends on your claims for damages. For example, if you took Zantac and were diagnosed with some form of cancer (or if a family member took Zantac and was diagnosed with cancer), you may be eligible to file a personal injury lawsuit against the manufacturers of Zantac and/or over-the-counter Zantac (OTC). An individual personal injury Zantac lawsuit allows people who developed cancer to obtain the maximum possible compensation for their injuries. Conversely, if you took Zantac and never developed cancer, you could still seek compensation by filing a class action lawsuit against the makers of prescription Zantac and/or Zantac OTC. A Zantac class action lawsuit allows consumers who purchased prescription Zantac or generic Zantac (ranitidine) to recover the money spent on purchasing the medication.

  • Q:Who Can Join the Zantac Class Action Lawsuit?

    A:Anyone who purchased Zantac and can prove they did so may be eligible to participate in a Zantac class action claim. Unlike individual lawsuits against Zantac’s makers, in a class action lawsuit, plaintiffs do not have to prove that they were harmed, only that that they purchased the drug and were not warned about the Zantac cancer risk. Such plaintiffs argue that they suffered economic losses because they purchased the drug believing it was safe and would not have made that purchase had they known about the risk of life-threatening Zantac adverse effects.

  • Q:Does Zantac Cause Cancer?

    A:Yes, Zantac can cause cancer. Zantac’s active ingredient, ranitidine, produces high levels of N-Nitrosodimethylamine (NDMA). The U.S. Food and Drug Administration (FDA), the Environmental Protection Agency (EPA), and the World Health Organization (WHO) classify NDMA as a cancer-causing chemical. The ranitidine molecule contains both a nitrite and a dimethylamine (DMA) group. These combine to form NDMA.

  • Q:Is Zantac Contaminated?

    A:No, we do not believe impurities or contaminants during manufacturing are what is causing the Zantac issue. The high levels of NDMA in Zantac are inherent to the molecular structure of ranitidine, meaning the drug is defective by design. In its April 2020 Zantac market withdrawal announcement, the FDA continued to use the term “impurity” when referring to NDMA in ranitidine. Our firm believes this is a mischaracterization of the issue; Zantac is a defective and dangerous drug that is capable of causing cancer.

  • Q:Should I Stop Taking Ranitidine?

    A:Yes. While the FDA continues to protect drug makers instead of the general public by failing to pull Zantac from the shelves, people should consult with their physicians about finding a suitable alternative.

  • Q:Is There a Safe Zantac Dosage?

    A:No. The high levels of NDMA in Zantac should deter patients from taking the medication. With several safe alternatives, consult with your physician about what Zantac substitute is best for you.

  • Q:Is There a Good Substitute for Zantac?

    A:Yes, there are several good alternatives to Zantac, including: Nexium (esomeprazole), Pepcid (famotidine), Prevacid (lansoprazole), Prilosec (omeprazole), and Tagamet (cimetidine). All of these drugs show no NDMA during testing. Pepsid and Tagament are good options for chemotherapy patients who were prescribed Zantac or Zantac OTC to control acid reflux, heartburn, and gastrointestinal reflux disease (GERD).

  • Q:What Will It Cost to Hire a Zantac Attorney?

    A:We provide free Zantac case reviews to anyone who fills out our contact form or calls our offices. It costs you nothing out of pocket to retain our law firm to represent you and pursue justice and compensation on your behalf. We don’t see a dime until we win your case.

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Join the Zantac Lawsuit

On Feb. 24, 2020, the judge overseeing the Zantac MDL (federal multi-district litigation) appointed our partner Brent Wisner to the Practices and Procedures team to help establish the protocols and methodology for litigating the tens of thousands of cases to be filed in the months and years to come. Brent also serves as Co-Chair of the Zantac Litigation Group for American Association for Justice and has been invited to deliver numerous Zantac presentations at prestigious national lawyer conferences across the nation.

Baum Hedlund Aristei & Goldman has earned a reputation for winning big cases against big companies. In practice for nearly 50 years, our firm has obtained more than $4 billion in verdicts and settlements across all areas of practice on behalf of people just like you. One our cases against Monsanto for Roundup cancer defects resulted in a $2.055 billion verdict for our clients, the second-largest personal injury verdict in the nation in 2019, and the ninth-largest personal injury verdict in American history. A similar case resulted in a $289.2 million verdict on behalf of our client, the second-largest jury verdict in the state of California for 2018.

Get Started Today

But our success isn’t just measured by the financial compensation we bring in on behalf of our clients. We are also committed consumer advocates who work tirelessly to protect people and the environment from harmful products. If you took Zantac and developed cancer, it is in your best interest to speak with an experienced personal injury attorney about filing a Zantac lawsuit. Based in Los Angeles and serving clients nationwide, our attorneys at Baum Hedlund have vast experience holding big corporations accountable for concealing the true dangers of consumer products.
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