Glyphosate Based Herbicide Study

Glyphosate-Based Herbicide Study Shows Multiple Ingredients are Toxic

Glyphosate-Based Herbicide Study Shows Multiple Ingredients Are ToxicScientists studying the toxic effects of glyphosate, 14 herbicides (including Roundup) that contain glyphosate, and several other chemicals (called “formulants” or “adjuvants”) also present in herbicides, have produced compelling evidence that glyphosate formulations are more toxic than glyphosate in isolation. Their findings lead to an unavoidable conclusion: regulatory agencies, which have approved glyphosate-based herbicides (GBH) primarily based on studies of glyphosate alone, have not properly scrutinized glyphosate formulations as they are used by consumers.

Glyphosate is Only One Ingredient Among Many in Herbicides Like Roundup

The researchers, Professor Gilles-Eric Séralini from the University of Caen Normandy, France, and his colleagues, Dr. Nicolas Defarge and Dr. Joël Spiroux, first tested glyphosate alone, on both plants and human cells, diluted to percentages that are recommended for agricultural use. They report, “No observable adverse effect was measured.”

In a second test, tomato plants were watered and sprayed for 7 days under the following exposure conditions:

  • Water only (control)
  • Glyphosate alone
  • POEA, polyethoxylated tallowamine, a surfactant. Surfactants are additional ingredients that help the herbicide cling to the leaf and increase herbicide leaf penetration.
  • Glycophan, a GBH, tested at recommended agricultural dilutions (RAD)
  • Roundup GT, a GBH, tested at RAD
  • Roundup Weathermax, a GBH, tested at RAD

Photos of the plants, which can be seen online on page 4 of the study, tell the story. Seralini and his team found that most of the toxic effects occurred during the first 5 days. Over the first 5 days, glyphosate alone “did not show any herbicidal activity.” The three GBH formulations, however, all showed clear toxic effects. As the photos suggest, the formulant POEA was highly herbicidal within three days of exposure.

“After 7 days, G [glyphosate] alone began to desiccate and to whiten a few upper leaves, only starting to demonstrate minor herbicidal effects, while plants had already been killed by all the other treatments except water (control C).”

Testing on human embryonic kidney cells produced similar results. The cells were killed by GBH formulations within 90 minutes, while glyphosate alone did not demonstrate similar toxicity. The authors report that the GBH formulations were thousands of times more toxic to the cells than glyphosate alone.

POEA demonstrated the same toxicity as the glyphosate-based herbicides. In fact, the researchers stated that the POEA formulant was 3,450 times more toxic than glyphosate alone. They believe that POEA may be “the real principal of toxicity” in the herbicide formulations that contain it.

The researchers also studied very low levels of exposure to the glyphosate formulations, formulants, and glyphosate alone. Even at levels that were not obviously toxic to the cells, all of the exposures produced endocrine disruption.

The study produced one other surprising finding: researchers found the heavy metals arsenic, chromium, cobalt, lead and nickel – all known to be toxic and endocrine disruptors – in 22 pesticides, including 11 glyphosate-based pesticides. (Herbicides are included in the pesticide category.)

  • Hardeman v. Monsanto Co. $80 Million
  • Dewayne “Lee” Johnson v. Monsanto Co. $289.2 Million
  • Pilliod et al. v, Monsanto Co. $2 Billion
/
  • Best Law Firms 2020
    Best Law Firms 2020

    The U.S. News – Best Lawyers® “Best Law Firms” rankings are based on lawyer evaluations, peer review from leading attorneys in their field, and review of additional information provided by law firms as part of the formal submission process.

  • AV Top Ranked Law Firm
    AV Top Ranked Law Firm

    Less than one-half of one percent of firms across the nation have achieved this ranking. A firm must have a high percentage of lawyers who have achieved the prestigious AV® Preeminent rating by Martindale-Hubbell®.

  • National Board of Trial Advocacy
    National Board of Trial Advocacy

    The National Board of Trial Advocacy is dedicated to bettering the quality of trial advocacy in our nation’s courtrooms and helping consumers find experienced and highly qualified trial lawyers.

  • Bar Register Preeminent Lawyers
    Bar Register Preeminent Lawyers

    The Bar Register is the definitive guide to the most distinguished law firms in America. It includes only those select law practices that have earned the highest rating in the Martindale-Hubbell Law Directory and have been designated by their colleagues as preeminent in their field.

  • Nation's Top 1%
    Nation's Top 1%

    The NADC is an organization dedicated to promoting the highest standards of legal excellence. Only the elite few attorneys are invited to join the NADC, less than 1% of practicing attorneys in the U.S.

  • Multi-Million Dollar Advocates Forum
    Multi-Million Dollar Advocates Forum

    Multi-Million Dollar Advocates Forum is one of the most prestigious groups of trial lawyers in the United States.  Membership is limited to attorneys who have won million and multi-million-dollar verdicts and settlements.

  • Super Lawyers
    Super Lawyers

    Super Lawyers is a rating service of outstanding lawyers from more than 70 practice areas who have attained a high-degree of peer recognition and professional achievement.

  • National Trial Lawyers Top 100
    National Trial Lawyers Top 100

    The National Trial Lawyers Top 100 recognized the law firms of Baum Hedlund Aristei & Goldman, the Miller Firm and Audet & Partners with the 2019 Trial Team of the Year award (in the Mass Torts category) for their work in the groundbreaking case of Dewayne “Lee” Johnson v. Monsanto Company.

  • Elite Trial Lawyers
    Elite Trial Lawyers

    NLJ and American Lawyer Media honor law firms and attorneys as Elite Trial Lawyers for their cutting-edge legal work on behalf of plaintiffs in practice areas ranging from mass torts to securities litigation.

  • AV Rated
    AV Rated

    An AV® rating reflects an attorney who has reached the heights of professional excellence. The rating signifies the highest legal ability, and very high adherence to professional standards of conduct, ethics, reliability, and diligence.

  • Listed in Best Lawyers
    Listed in Best Lawyers

    Best Lawyers is the oldest and most respected peer-review publication in the legal profession. A listing in Best Lawyers is widely regarded by both clients and legal professionals as a significant honor, conferred on a lawyer by his or her peers.

/

Glyphosate-Based Herbicide Study Shows Cancer Linked Chemical May Be the Least of Our Worries

The results of this testing, according to Seralini and his colleagues, indicate that glyphosate may be the least toxic substance in most glyphosate-based herbicides. This raises a serious problem, because it is testing on glyphosate that is used by regulatory agencies to determine acceptable levels of exposure GBH formulations such as Roundup. Surfactants and other formulants, if they are known (manufacturers are not required to identify the inert ingredients in their pesticides) are not tested for long-term health effects.

The authors of this glyphosate-based herbicide study make two important recommendations:

  1. Regulatory experiments to determine acceptable daily intake of herbicides should be performed with the “full formulations and all components” of the herbicides being assessed.
  1. The same full formulations and components should be declared and measured to identify all the active ingredients in the herbicides.

Summary Information

Title
Toxicity of formulants and heavy metals in glyphosate-based herbicides and other pesticides

Authors
N. Defarge1, J. Spiroux de Vendômois2, G. E. Séralini1

  1. University of Caen Normandy, Department of Biology and Network on Risks, Quality and Sustainable Environment MRSH, Esplanade de la Paix, 14032 Caen Cedex, France
  1. CRIIGEN, 81 Rue Monceau, 75008 Paris, FranceNetwork on Risks, Quality and Sustainable Environment MRSH, University of Caen Normandy, Esplanade de la Paix, CS 14032, Caen Cedex 5, France

Journal
Toxicology Reports, 5 (2018), 156-163. Available online December 30, 2017

Funding
This work was supported by the University of Caen and the Committee of Research and Independent Information on Genetic Engineering (CRIIGEN). It received funding from Alibio Institute and Ekibio Foundation, the Regional Council Ile de France, the Regional Council Rhône-Alpes, JMG Foundation, Foundation Lea Nature, Nature Vivante, Malongo, and the Sustainable Food Alliance. The authors wish to thank the European Deputy Michèle Rivasi for the support to accomplish this work.

Firm Reviews

What Our Clients Are Saying
  • Top Legal Minds in the Country

    “The Baum, Hedlund firm has some of the top legal minds in the country; they are driven, determined, trustworthy, ethical and passionate.”

    - From Best Lawyers® Best Law Firms
  • I Can’t Imagine a Better Law Firm

    “Multiple lawyers recommended Baum Hedlund to me and I have been consistently impressed with the quality of their work.”

    - Best Law Firms Survey
  • Diligent & Professional Representation

    “Thanks to your efforts I was able to recover from a tragic experience and turn my life around for the best.”

    - W.T.
  • Our Best Interest Was Always Number One on Your List

    “A special thank you to your Spanish-speaking staff for the extra effort put into this case. The language barrier was never a problem, and we are so very thankful to them. Your name holds much respect in our family.”

    - G.C. & C.C
  • We Have Never Met a More Wonderful Group of People

    “It is obvious that the people at Baum, Hedlund, Aristei, & Goldman believe in what they do. And that you all really care about your clients.”

    - The B. Family
/