Antidepressant Studies

Effexor and Pristiq Linked to Increased Risk of Violence

According to an Institute for Safe Medication Practices study published in the journal PloS One and based on data from the FDA’s Adverse Event Reporting System, Venlafaxine (Effexor) is 8.3 times more likely than other drugs to be related to violent behavior.  Effexor has been identified as one of 31 drugs that are disproportionately linked with reports of violent behavior towards others.

The antidepressant Desvenlafaxine (Pristiq), is 7.9 times more likely to be associated with violence than other drugs according to the same study.

Top Ten Legal Drugs Linked to Violence –

Prescription Drugs Associated with Reports of Violence Towards Others  – Public Library of Science; published December 15, 2010.

Summary Information


Prescription Drugs Associated with Reports of ViolenceTowards Others


Thomas J. Moore 1; Joseph Glenmullen 2; Curt D. Furberg 3

  1. Institute for Safe Medication Practices, Alexandria, Virginia, United States of America
  2. Department of Psychiatry-Cambridge Hospital, Harvard Medical School, Cambridge, Massachusetts, United States of America
  3. Division of Public Health Sciences, Wake Forest University School of Medicine, Winston-Salem, North Carolina,United States of America


PLoS ONE. 2010, Vol. 5 Issue 12, p1-5


The authors have no support or funding to report.