Antidepressant Studies

Date: March 2014

Study Title: Preterm Birth and Antidepressant Medication Use during Pregnancy: A Systematic Review and Meta-Analysis

Publication: PLoS One

Drugs: SSRI and SNRI antidepressants

A comprehensive review of 41 studies confirms previous findings of a significant link between maternal antidepressant usage and preterm birth. Researchers at Harvard Medical School, Vanderbilt University and Tufts University School of Medicine found that antidepressant usage at any time during pregnancy increased the risk of preterm birth by 61%, even after adjusting the figures for the possible influence of depression itself. Mothers who used antidepressants during the third trimester doubled their risk of having a preterm birth.

Date: January 14, 2014

Study Title: Prenatal exposure to antidepressants and persistent pulmonary hypertension of the newborn: systematic review and meta-analysis

Publication: British Medical Journal

Drugs: SSRI antidepressants

A meta-analysis published in the British Medical Journal on January 14, 2014, has reported that maternal use of SSRI antidepressants more than doubles the risk of persistent pulmonary hypertension, a serious lung complication, in newborn babies.

Date: December 26, 2012

Study Title: Association between Reported Venlafaxine Use in Early Pregnancy and Birth Defects, National Birth Defects Prevention Study

Publication: Birth Defects Research, Part A: Clinical and Molecular Teratology

Drugs: Effexor – venlafaxine

An epidemiological study of birth defects in the United States has added new evidence to a growing body of data linking antidepressant usage during pregnancy to miscarriage and birth defects, including serious congenital heart defects.

Date: December 15, 2010

Study Title: Prescription Drugs Associated with Reports of Violence Towards Others

Publication: Public Library of Science

Drugs: Celexa – citalopram, Effexor – venlafaxine, Lexapro – escitalopram, Prozac – fluoxetine

According to an Institute for Safe Medication Practices study published in the journal PloS One and based on data from the FDA’s Adverse Event Reporting System, Venlafaxine (Effexor) is 8.3 times more likely than other drugs to be related to violent behavior.

Date: May 31, 2010

Study Title: Use of Antidepressants During Pregnancy and the Risk of Spontaneous Abortion

Publication: Canadian Medical Association Journal

Drugs: Effexor – venlafaxine

Adding to the growing list of worries associated with antidepressants, a new study has found that the risk of miscarriage is significantly higher in women who take SSRI (selective serotonin reuptake inhibitor) and SNRI (serotonin-nonrepinephrine reuptake inhibitor) antidepressants, such as Effexor, early in their pregnancies.

Date: March 2010

Study Title: Fetal Exposure to Antidepressants and Normal Milestone Development at 6 and 19 Months of Age

Publication: Pediatrics

Drugs: Celexa – citalopram, Effexor – venlafaxine, Zoloft – sertraline

Recent research has linked prenatal exposure to antidepressants with developmental milestone delays in early childhood.